Jenner has consistently denied rumors that she takes weight-loss drugs, but has been public about undergoing a facelift in 2025.

Kris Jenner got ‘so sick’ when she tried Ozempic: ‘I can’t work anymore’

Jenner has consistently denied rumors that she takes weight-loss drugs, but has been public about undergoing a facelift in 2025.

By Ryan Coleman

Ryan Coleman

Ryan Coleman is a news writer for with previous work in MUBI Notebook, Slant, and the LA Review of Books.

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May 7, 2026 5:19 p.m. ET

Kris Jenner in 2026. Credit:

Cindy Ord/MG26/Getty

- Kris Jenner is taking fans inside her harrowing experience with the weight-loss drug Ozempic.

- The *Kardashians *star says she tried the GLP-1 "when no one knew what it was," but got "so sick" as a result.

- Jenner also opened up about getting "a very well-known facelift a year ago."

Kris Jenner isn't above some nipping and tucking, but she draws the line at GLP-1s.

The reality star and momager extraordinaire recently pulled back the curtain on her beauty and wellness regimen, revealing that weight-loss drugs like Ozempic have no place.

After discussing surgical intervention, amino acid treatments, and the importance she places on routine blood work on Tuesday's episode of the *SHE MD *podcast, Jenner noted, "I did not do like an Ozempic. I tried it. We tried it once when no one knew what it was, and it made me really sick."

Kris Jenner in 2019. Jamie McCarthy/Getty Images

Jenner said she called her doctor after experiencing an adverse reaction from the injectable to tell her, "'I can't work anymore. I can't, I'm so sick. I'm like, nauseous.' And so she goes, 'Okay, okay, let's try something else.'"

So, Jenner said that she and her doctor dialed around and looked at different options, leading to her ultimate realization that "a peptide injection was really great for me."

Peptides are short chains of organic compounds called amino acids that join to form proteins. Due to the simplicity of their structure, they have been adopted for injectable wellness procedures for their purported benefits with regard to metabolism, inflammation, and hormone regulation. Research has indicated that some patients report pain relief and anti-inflammatory effects after peptide shots, but there is yet no unanimous medical opinion regarding the treatment.

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Ozempic, meanwhile, belongs to a class of drugs called GLP-1s, which most often contain the medication semaglutide, originally approved by the FDA in 2017 to treat type II diabetes. The drug promotes the production of insulin, thereby lowering blood sugar and curbing appetite, which is why so many have turned to Ozempic for weight loss.

Celebrities like Serena Williams have caused controversy for taking and promoting GLP-1s, though the tennis star told PEOPLE last August that she feels "good and healthy" receiving the injections once per week.

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Not for Jenner, however. The reality star continued to praise "supplements," and explained, "I get my blood drawn every three months just to keep my hormones balanced, because I realized after I was 45 that was so important to your physical female health, just to keep that balanced."

She also joked that health and wellness aside, she "had a very well-known facelift a year ago," which she described as "helpful."

You can watch Jenner's full interview on the *SHE MD *podcast above.

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